Thyroid Disorder in Systemic Lupus Erythematosus Patients in Southeast Iran

lranian journal of Clinical Infectious Diseases

Sandooghi M¹  Z Zakeri² 

[1] Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran,;Assistant Professor, Department of Internal Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

关键词: SLE;    thyroid dysfunction;    hypothyroidism;    hyperthyroidism;    anti TPO antibody;   

DOI  :  10.17795/semj20382

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:WeconductedthisstudytoclarifytheprevalenceofthyroiddysfunctioninpatientswithSystemicLupusErythematosus(SLE)andcomparedittoamatchedhealthycontrolsgroup.Materialandmethods:Eighty-threeSLEand166matchedhealthycontrolsunderwentclinicalexaminationandlaboratoryevaluationforserumT3,T4,TSHandThyroidperoxidesantibody(TPOAB).Results:24.1%ofSLEpatientsand13.3%ofcontrolgrouphadthyroiddysfunction(pvalue=0.04).ClinicalthyroiddysfunctionwasseenneitherinSLEpatientsnorinthecontrolgroup.ElevatedTSHlevelswerethemostcommondysfunction(19.3%)oftheSLE,comparedwithcontrolgroup(5.4%).PositiveTPOantibodywasdetectedin16.9%ofSLEand16.3%ofthecontrolgroup.MeanlevelofTPOantibodywashigherinSLEpatientswiththyroiddysfunction(137.05)thanSLEpatientswithoutthedisorder(30.8)(pvalue=0.007).Conclusion:WeconcludedthyroiddysfunctionwasmorefrequentinSLEpatientsthaninhealthycontrols.Moreover,SLEpatientswithantiTPOweremorelikelytohavethyroiddysfunctionthanthecontrolgroup.

【 授权许可】

Unknown