The Frequency of Consanguineous Marriages and Their Effects on Offsprings in Tabriz City

lranian journal of Clinical Infectious Diseases

A Mirza Aghazade²  M Pourbarghi⁴  SA Rahmani⁵  F Aboualsoltani¹  H Dolatkhah³ 

[1] General Practitioner;Assistant Professor of Biostatics, Tabriz University of Medical Sciences, Tabriz, Iran.;Pediatrician, Taleghani Hospital;Student of Medicine;Assistant Professor of Medical Genetics

关键词: Consanguineous marriage;    congenital malformation;    Trisomy 21;    genetic disease;   

DOI  :  10.17795/semj20379

学科分类：基础医学

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Toomuchdiversityandaneverincreasingnumberofgeneticdisordersappearasabigchallengeinthecomingfuture.Oneofthemainsourcesofgeneticdisordersistheconsanguineousmarriageswhichare,unfortunately,verycommoninoursociety.Objectives:Inordertoprepareourselvestoacceptthechallengesregardingcongenitalmal-formationsduetoconsanguineousmarriages,thefirststepistogetcompleteinformationoftheirprevalenceandtheirriskfactors.Methods:Thestudywasmadeduring2003-2007inthecityofTabriz,Iran.Weselected6000familiesanddatawasobtainedviaaquestionnairecomprisedofinformationincludingmaritalages,numberofpregnancies,typeofdelivery,ratioofconsanguineousandnonconsan-guineousmarriages,jobsofparents,andeffectsonchildmalformationsResults:Consanguineousmarriagesofalltypeswererelatedwithincreasedcongenitalmal-formations(withratio43/1000forconsanguineousmarriagesandfornonconsanguineousmarriages28/1000).Motheragelessthan18andmorethan35particularlywasaccompa-niedwithincreasedmalformationswhileeducationofmothercameouttobeinverselyrelatedtocongenitalmalformationConclusion:Increasedstillbirths,consanguineousmarriageandmalformations,especiallyofmusculoskeletalsystem,requirenewplanningonanationalleveltocontrolandinformpeo-pleoftheconsequencesofconsanguineousmarriages.

【 授权许可】

Unknown