期刊论文详细信息
lranian journal of Clinical Infectious Diseases | |
Isolation of Enteropathogenic Escherichia coli from Children with Diarrhoea Attending the National Hospital in Abuja, Nigeria. | |
MM Onojo1  JD Mawak2  YT Kandakai-Olukemi2  | |
[1]BSc Student, Department of Microbiology, Faculty of Natural Sciences, University of Jos, Jos, Nigeria. | |
[2]Associate Professor, Department of Medical Microbiology, Faculty of Medical Sciences, | |
关键词: Enteropathogenic Escherichia coli (EPEC); diarrhoea; children; serotype; Abuja; Nigeria; | |
DOI : 10.17795/semj20495 | |
学科分类:基础医学 | |
来源: Shiraz University of Medical Sciences | |
【 摘 要 】
Background::Diarrhoealdiseasesremainoneoftheleadingcausesofchildhoodmorbidityandmortalityinmostdevelopingcountries,withenteropathogenicEscherichiacoli(EPEC)beingoneofthemostimportantaetiologicagentsofinfantilediarrhoeainmanyofthesecountries.Objective::TodeterminetheprevalenceofEPECinchildren(0-24months)withdiarrhoea.Methods::OnehundredstoolsamplesfromchildrenwithdiarrhoeaattendingtheNationalHospitalinAbuja,NigeriawereanalysedforthepresenceofEPECusingstandardbacteriologicalmethods.Isolateswerealsosubjectedtoantimicrobialtestingusingthediscdiffusionmethod.Results::Fifteen(15.00%)sampleswerepositiveforEPEC.Thehighestnumberofisolateswasrecoveredfromthe6-12monthsagegroupwith10(20.41%)intotal.Noisolateswererecoveredfromthe0-5monthsagegrouporfromexclusivelybreastfedchildren,however,nine(19.15%)childrenreceivingmixedfeedingandsix(33.33%)childrenwhowerenotbeingbreast-fedtestedpositiveforEPEC,andthedifferencewasfoundtobestatisticallysignificant(P#60;0.05).Thehighestnumberofisolates,eight(53.33%),belongedtothoseinthepoly1sero-groupwithserotypesO1,O26,O86a,O111,O119,O127andO128.Fourteen(93.33%)oftheisolatesweresensitivetonorfloxacin,13(86.67%)eachtoofloxacinandcolistin,11(73.33%)tonalidixicacid,10(66.67%)tocefuroxime,two(13.33%)tocotrimoxazole,andone(6.67%)totetracycline.Noneoftheisolateswerefoundtobesensitivetoampicillinorchloramphenicol.Conclusion::ThisstudyhasshownthatmultidrugresistantEPECisassociatedwithinfantilediarrhoeainAbuja,Nigeria.Toaddressthisissue,antibiotictherapyshouldtakeintoconsiderationthesusceptibilitypatternofthepathogen.Inaddition,theincidenceofEPECinchildrencanbetracedprimarilytofaultyweaningpracticesand/orpoorpersonalhygiene.【 授权许可】
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