Effects of Oral Anti-diabetic Agent Sitagliptin on Total Antioxidant and Oxidant Status in Rats with Type 2 Diabetes Mellitus

Journal of Applied Biological Sciences

Sefa ÇELİK¹  Ömer HAZMAN¹ 

关键词: Type 2 diabetes;    Sitagliptin;    Oxidative stress;    TAS;    TOS;    OSI;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Withthepresentedstudy,itisaimedtoexaminetheeffectofdipeptidylpeptidase(DPP)4inhibitorsitagliptin,whichisanoralanti-diabeticmedicine,ontotalantioxidantandoxidantstatusintheratswhichwereinducedwiththeexperimentaltype2diabetes(T2DM)model.Thestudywasplannedtocover24weeks.Inratsthatareleftoutofthecontrolgroup,after8weeksofHigh-FatDiet(HFD)feeding,theexperimentalT2DMmodelwasconstructedbyalowdoubledosestreptozotocin(STZ)injectionperweek.Sitagliptinwasappliedtotreatmentgroupsatadoseof10mg/kg-day.Attheendofthestudy,FastingPlasmaGlucose(FPG),ALT,AST,LDH,HbA1c,insulin,TotalAntioxidantStatus(TAS),TotalOxidantStatus(TOS)levelsandOxidativeStressIndex(OSI),HOMA-IRandHOMA-βindicesweremeasured.ItwasdeterminedthatsitagliptindecreasedFPGandHbA1clevels,increasedinsulinlevels,anddidnotaffectALT,AST,LDH,TOSlevelsandOSIinthediabetictreatmentgroupcomparedtothediabeticgroup.However,itwasidentifiedthatsitagliptindecreasedTASlevelsinpancreatictissueindiabeticrats,anddecreasedTOSlevelsandOSIintheHFDgroup.Itwasdetectedthatindiabeticratssitagliptinbalancesglucosehomeostasisandprotectsbetacells;whereasitincreasesoxidativestressinpancreatictissueandconverselyitdecreasesoxidativestressinpre-diabeticobeserats(HFDgroups).

【 授权许可】

Unknown