Effect of Oxytetracycline and Florfenicol on the Cytogenetic Picture of Nile Tilapia (Oreochromis niloticus) Fish

Journal of Applied Biological Sciences

Magdi A. SOLTAN¹  Mona G. MOHAMED¹  Hasnaa A. RADWAN¹  Abdel-Karim I.M. EL-SAYED¹ 

关键词: oxytetracycline - florfenicol – chromosomal aberrations – micronuclei- tilapia fish.;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Oxytetracycline(OTC)andflorfenicol(FF)areantibioticswithhighpotencyagainstthebacterialdiseases.Therefore,theyarecommonlyusedagainstbacterialinfectioninfishfarming.Thepresentworkaimedtostudytheeffectofdifferentdosesofoxytetracycline(0,40,80,120mg/kgbasaldiet)andflorfenicol(0,7.5,15,22.5mg/kgbasaldiet)onchromosomalstructureandmicronucleiinductioninRBCsofNiletilapiafish.Theresultsrevealedthatthedoseof40mgOTC/kgbasaldietandthedoseof7.5mgFF/kgbasaldietshowednon-significantincreasesinchromosomalaberrationscomparedwithcontrol.Thesamedoseofflorfenicolcausedsignificancedifferenceinthefrequencyofmicronucleicomparedwithcontrolgroup.TheotherdosesofOTCandFFweresignificantincreases(p<0.05)intotalchromosomalaberrations(11.4015.60and16.8019,respectively)andthefrequencyofmicronuclei(5.46.8and6.48.5,respectively)comparedwithcontrolgroup(8and2.4,respectively).Themutagenicinfluenceoftherapeuticandsuper-therapeuticdosesofFFtreatmentwasmoreobviousonchromosomalstructureandmicronucleifrequencycomparedtotherapeuticandsuper-therapeuticdosesofOTCtreatment.Thesefindings,ingeneral,addtothefactthatfishsuchastilapia(Oreochromisniloticus)isapromisingmodelsinvivoformonitoringthemutageniceffectofsubstancesonaquaticecosystems.

【 授权许可】

Unknown