Journal of Applied Biological Sciences | |
Effect of Oxytetracycline and Florfenicol on the Cytogenetic Picture of Nile Tilapia (Oreochromis niloticus) Fish | |
Magdi A. SOLTAN1  Mona G. MOHAMED1  Hasnaa A. RADWAN1  Abdel-Karim I.M. EL-SAYED1  | |
关键词: oxytetracycline - florfenicol – chromosomal aberrations – micronuclei- tilapia fish.; | |
DOI : | |
学科分类:生物科学(综合) | |
来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente | |
【 摘 要 】
Oxytetracycline(OTC)andflorfenicol(FF)areantibioticswithhighpotencyagainstthebacterialdiseases.Therefore,theyarecommonlyusedagainstbacterialinfectioninfishfarming.Thepresentworkaimedtostudytheeffectofdifferentdosesofoxytetracycline(0,40,80,120mg/kgbasaldiet)andflorfenicol(0,7.5,15,22.5mg/kgbasaldiet)onchromosomalstructureandmicronucleiinductioninRBCsofNiletilapiafish.Theresultsrevealedthatthedoseof40mgOTC/kgbasaldietandthedoseof7.5mgFF/kgbasaldietshowednon-significantincreasesinchromosomalaberrationscomparedwithcontrol.Thesamedoseofflorfenicolcausedsignificancedifferenceinthefrequencyofmicronucleicomparedwithcontrolgroup.TheotherdosesofOTCandFFweresignificantincreases(p<0.05)intotalchromosomalaberrations(11.4015.60and16.8019,respectively)andthefrequencyofmicronuclei(5.46.8and6.48.5,respectively)comparedwithcontrolgroup(8and2.4,respectively).Themutagenicinfluenceoftherapeuticandsuper-therapeuticdosesofFFtreatmentwasmoreobviousonchromosomalstructureandmicronucleifrequencycomparedtotherapeuticandsuper-therapeuticdosesofOTCtreatment.Thesefindings,ingeneral,addtothefactthatfishsuchastilapia(Oreochromisniloticus)isapromisingmodelsinvivoformonitoringthemutageniceffectofsubstancesonaquaticecosystems.
【 授权许可】
Unknown
【 预 览 】
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