| Journal of Applied Biological Sciences | |
| The Status of the P53 Gene and Human Papilluma Virus İnfection in Cervical Carcinoma Patients | |
| Mandana BEHBAHANI1 Mehrnaz SHANEHSAZZADEH1 Abbasali POURAZAR1 | |
| 关键词: single-stranded conformation polymorphism; suppressor gene; HPV; PCR technique; Iranian women.; | |
| DOI : | |
| 学科分类：生物科学（综合） | |
| 来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente | |
 PDF
|
|
【 摘 要 】
Humanpapillomavirus(HPV)infectionsofthehigh-risktypesarestronglylinkedtothedevelopmentofcervicalcarcinoma.TheHPVoncoproteinsE6andE7arethoughttoplayacrucialroleinthisprocessthroughtheirinteractionswiththeP53protein.E6bindstoP53proteinpromotingitsdegradation.ThisisconsideredtocontributetotheoncogenesisofHPV-associatedanogenitalcancer.Ontheotherhand,inHPVnegativecervicalcarcinoma,P53mutationsarethoughttohavearoleinthetransformationprocess.In25formaldehyde-fixedparaffinembeddedcervicalcarcinomatissuesampleswereevaluatedforthepresenceofHPV-DNAandmutationsinexons5-8oftheP53genebysingle-strandedconformationpolymorphismanalysis.FourteensampleswereHPVpositiveandonly3missensepointmutationsweredetected.ThesefindingssuggestthatothermechanismsindependentofP53inactivationmayplayaroleinthegenesisofcervicalcarcinomas.
【 授权许可】
Unknown
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201912090818597ZK.pdf | 609KB |  download |
878987797
028-85220240
