Molecular Markers in Cancer Diagnosis and Management: A Review

Journal of Applied Biological Sciences

Nataraja Thamizh SELVAM¹  S. DAMODARKUMAR¹  Preetham ELUMALAI¹  V.VENKATAKRISHNAN¹ 

关键词: Molecular markers;    tumour;    Cancer markers;    AFP;    CEA;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Cancerisafamilyofdiseasesthatinvolveuncontrolledcelldivisionandtissueinvasiveness.Itmayaffectalmostanytissueofthebody.Lung,prostate,breast,colorectalandstomacharethefivemostcommoncancersintheworld.Morethan10millionpeoplearediagnosedwithcancereveryyear.Tumourmarkersarebiologicalsubstanceswhichcanbemeasuredinbloodandotherbodyfluids.Increasedconcentrationindicatesthepresenceofatumour.Manydifferentsubstancescanbeusedastumourmarkers,butthetermgenerallyreferstosubstancesproducedbythetumourcellsandgenerallyfoundinverylowconcentrationinthebodyfluidsofnormalindividuals.Anidealtumourmarkershouldbeusedforscreening,diagnosisandmonitoringofdiseaseprogression.Unfortunatelythereisnoidealtumourmarker.Confusionexistsaboutthevalueoftumormarkersinapatientwithcancerofunknownprimary.Intuitively,apaneloftumormarkersshouldhelptoestablishtheoriginofthetumor.Unfortunately,mosttumormarkersaretoononspecificforthispurpose.Thisreviewarticlecriticallyanalysesaboutvariousmolecularmarkersofcancerandtheirroleindiseasediagnosisandtreatmentevaluation.

【 授权许可】

Unknown