Effects of Chronic Exposure to Cobalt Chloride on the Fertility and Testes in Mice

Journal of Applied Biological Sciences

Wajih OWAIS¹  Rawdah K. AL-THAN¹  Aisha S. AL-THA¹  Homa DARMANI¹  Ahmed ELBETIEHA¹ 

关键词: CoCl2;    Swiss mice;    reproductive system;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Theeffectoftwelveweeksingestionofcobaltchloride(CoCl2)wasinvestigatedonthefertilityofadultmaleSwissmice.Sexuallymaturemalemicewereexposedto200,400and800ppmcobaltchloridedissolvedindrinkingwater.Basedonfluidconsumption,exposedanimalsreceivedanaverageof25.66±2.34,46.91±4.78and93.01±6.76mg/kg/daycobaltchloride,respectively.Aftertheexposureperiod,thesemaleswerematedwithuntreatedfemalemice.Fertilitywassignificantlyreducedinmalesthatingestedcobaltchloride.ThenumberofpregnantfemalesandthenumberofimplantationsitesweresignificantlyreducedinfemalesmatedwithmalesthathadingestedCoCl2ataconcentrationof400or800ppm.ThetotalnumberofresorptionsandthenumberoffemaleswithresorptionsweresignificantlyincreasedinfemalesmatedwithmalesthathadingestedCoCl2atallconcentrations.Ontheotherhand,thenumberofviablefetuseswasdecreasedinfemalesimpregnatedbyexposedmalesatthethreeconcentrations.Absoluteepididimalweight,andtherelativeorabsolutetestesweightsweresignificantlyreducedinmalesthatingestedcobaltchlorideataconcentrationsof400or800ppm.Incontrast,absoluteandrelativeweightsoftheseminalvesiclesweresignificantlyincreased.Furthermor,epididymalandspermcountsanddailyspermproductionweresignificantlydecreasedinmalesthatingestedCoCl2.HistologicalevaluationofthetestesrevealedseveralabnormalitiesincludinghypertrophyoftheinterstitialLeydigcells,congestedbloodvessels,degenerationofthespermatogonialcellsandnecrosisofboththeseminiferoustubulesandtheinterstitialtissue.

【 授权许可】

Unknown