The Effects of Aspirin and Vitamin E on Blood Antioxidant Enzymes of Rats during Experimental Liver Ischemia-Reperfusion

Journal of Applied Biological Sciences

Birsen KILIÇOĞLU¹  AYDIN Zafer EREN¹ 

关键词: ischemia/reperfusion;    superoxide dismutase;    catalase;    glutathione peroxidase;   

DOI  :  

学科分类：生物科学（综合）

来源: Nobel Bilim ve Arasirma Merkezi/Nobel Science and Research Cente

【 摘 要 】

Damagecausedbyfreeoxygenradicalsisquiteimportantinischemia/reperfusion(I/R).Therefore,ourstudyfocusesontheeffectsofAspirinandVitaminEontheactivitychangesinerythrocyteradicalscavengingenzymesinsuperoxidedismutase(SOD),catalase(CAT)andglutathioneperoxidase(Gpx)activitiesfollowingliverischemia/reperfusioninrats.Winstaralbinomaleratsweredividedintosixgroupsassham,isotonicsalinesolventAspirin,VitaminEsolventcornoilinjectedcontrolgroupsandAspirin,VitaminEandAspirin+VitaminEinjectedtestgroups.Ratssubjectedtoischemiawerethengroupedandexposedtoreperfusionatthe0th,2nd,8thand24thhours.Afterreperfusion,bloodsamplesweretakenviaadispossibleinjectorfromtheheartatthesehoursandtheenzymeactivitieswerestudiedinerythrocytefractions.Enzymeactivitychangeswereseenduringreperfusionperiods,particularlythe2ndhourofreperfusionmorestrikingthaninischemiaperiod.WhenAspirinandVitaminEweregivenseparatelycausedenzymeactivitychangesbutthesechangesmoreremarkablewhenAspirinandVitaminEgiventogether.Consideringtheseresults,AspirinandVitaminEmaybesuggestedtopreventpost-ischemicdamageowingtotheirpotentialtherapeuticeffects.

【 授权许可】

Unknown