Quantitative calprotectin: a new potentially valuable biomarker of gastro-intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Cellular Therapy and Transplantation

Ruslana V. Klementjeva¹  Boris V. Afanasyev¹  Oleg V. Goloschapov¹  Igor N. Zubarovskiy¹  Vladimir N. Vavilov¹  Natalia V. Stancheva¹  Sergej N. Bondarenko¹  Yulia G. Vasilieva¹ 

关键词: allogeneic HSCT;    graft-versus-host-disease;    calprotectin;   

DOI  :  10.3205/ctt-2010-No9-abstract81

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Background.Thegastrointestinalformofgraft-versus-hostdisease(GI-GVHD)isoneofthemostdangerouscomplicationsafterallogeneichematopoieticstemcelltransplantation(HSCT).Itsdiagnosisisusuallyconfirmedbybiopsy,neverthelessitisveryveritabletofindbiomarkersofearlydamageofgastrointestinalmucosaatlevelswhichcouldalsoreflecttreatmentefficacy.Objective.TheaimofourstudywastodeterminethevalueoffecalcalprotectinlevelsfordiagnosticsofGI-GVHD.Materialandmethods.Fecalcalprotectinlevelswerestudiedin27patientsafterallogeneicHSCTwithacuteenterocolitis.Allpatientsunderwentacolonoscopywithbiopsy.ThediagnosisofGI-GVHDwasconfirmedhistologicallyin11patients.Thefecalcalprotectinlevelwasnotedinthefirst48hoursafterthebeginningofdiarrheaandthenmonitoredweekly.Results:Weobservedsignificantlyhigher(plt;0.005)levelsofcalprotectininpatientswithGI-GVHD(n=24,mean:5468ng/mL,range224–10000ng/mL),comparedwithpatientswithoutGI-GVHD(n=24,undetectablelevel,range0–50ng/mL).Thisalsocorrelateswiththeresultsofhistopathologicalstudyandwasmorespecificthanmacroscopicresults.Inpatientswithapositiveresponsetoimmunosuppressivetreatmentastatisticallysignificantdecreaseofthecalprotectinlevelwasobservedduringfirsttwoweeksoftherapy.Conclusion:WeproposethatfecalcalprotectinlevelsareapotentiallyvaluablemarkerforrapiddiagnosticofGI-GVHDwithhighsensitivityandspecificity.Thiscouldbeusefulforimmunosuppressivetreatmentefficacymonitoring.

【 授权许可】

Unknown