Cellular Therapy and Transplantation | |
High dose chemotherapy with PBSC support in pediatric brain tumor patients | |
Igor S. Dolgopolov1  Ekaterina M. Tarasova1  George L. Mentkevich1  Boris V. Cholodov1  Maksim Y. Yankelevich1  Sergei K. Gorelushev1  Michail S. Laskov1  | |
关键词: brain tumors; high dose chemotherapy; hematopoietic peripheral stem cells; | |
DOI : 10.3205/ctt-2010-No9-abstract28 | |
学科分类:肿瘤学 | |
来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf | |
【 摘 要 】
TheroleandplaceofHDCTwithHSCsupportinthetreatmentofpediatricbraintumorsremainscontroversial.In2008westartedaprotocol:Thetreatmentofpatientswithbraintumorsundertheageof3yearswithintensivechemotherapy(NeuroIPO).Currently35ptsareincludedinthestudywiththefollowupdiagnosesbeing:ependimoma,12,medulloblastoma,13,CPC,1,ATRT,6,andsPNET,4.Themediumageatdiagnosiswas19.7m.FiveptsreceivedtandemtransplantswithASCrescueafterCBDCA/TMZ/CPMandCBDCA/TMZ/MELregimensasaconsolidation.Threeoutoffiveptsarealiveanddiseasefreeformorethanoneyear.Two-yearEFSforthewholegroupis42%.From2009wehavebeenpilotingaconditioningregimenwherecraniospinalirradiationiscombinedwithmelphalanandtopotecan.ThefirstlevelofRTis10Grey,andshowsnomajorunexpectedtoxicity.Since2009theMoscowneurooncologygrouphasbeenconductingatrailwithintensivechemotherapywithHSCsupportinptswithmedulloblastomawhoaremorethan4yearsofage(modifiedSt.Jude2003protocol).AftersurgeryandconformalRTtotheresidualtumor/ortumorbedptsaretreatedwith4coursesofCT(Cyclo+CDDP+Vcr),eachwithHSCsupport.Todate10ptsareincluded.Totalamountofcoursesdelivered:30.Amediannumberof1.45(0.7–2.7)х106/kgCD34+wasreinfusedaftereachcourseofCT.Thetoxicityoftherapywasmainlyhematological.NoTRMwasregistered.5ptshavefinishedtheirtreatment.NoneoftheptsprogressedonCTandhaverelapsedinthisshortperiodofobservationtodate.
【 授权许可】
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