Cellular Therapy and Transplantation | |
The long-term outcome of BFM-based therapy for childhood lymphoblastic lymphoma in the Moscow region | |
Dmitry A. Peregudov1  Elena V. Samochatova1  Stanislava S. Kulikova1  Sergey V. Semochkin1  Eugenia V. Inyushkina1  Natalya V. Myakova1  Dmitry M. Konovalov1  Dmitry V. Litvinov1  Lyudmila V. Baydun1  Larisa N. Shelehova1  Konstantin L. Kondratchkik1  | |
关键词: lymphoblastic lymphoma; non-Hodgkin’s lymphoma; children; adolescents; therapy; NHL-BFM 90/95; | |
DOI : 10.3205/ctt-2010-No9-abstract50 | |
学科分类:肿瘤学 | |
来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf | |
【 摘 要 】
Lymphoblasticlymphoma(LBL)isoneofpredominantchildhoodnon-Hodgkin’slymphoma(NHL)subtypes.However,excellentoutcomeshavebeenachievedwithacutelymphoblasticleukemia(ALL)-typetreatmentsinchildrenwithLBL.ThepurposeofthisstudywastoinvestigateoutcomeschildrenandadolescentswithLBLtreatedwiththeNHL-BFM90and95protocolsintheMoscowregion.Methods:58pts(m,-40;f,-18)wereenrolledinthisstudyfromMay1991toAugust2008.Fifty-two(90%)ptsweretreatedwiththeALL-liketherapyprotocolNHL-BFM90or95fornon-B-NHL(ALL-type)patients,and6(10%)–withNHL-BFM90forB-NHL.Theseprotocolsdifferedfromtheoriginalbyreductionofthemethotrexatedose(1g/m2/24hinsteadof5g/m2/24h).Results:Themedianageattimeofpresentationwas11.0(range1.5–21.6)years.Forty-five(90%)ptshaveaT-cellimmunophenotype.Fifty-three(91%)hadadvanced(III,IV)stagedisease.ThepresentingsitesofT-LBLincludedmediastinalmassandbonemarrowin35(78%)and13(29%)casesrespectively.CRwas94and83%fornon-B-NHLandB-NHLtreatmentrespectively.Five-yeareventfreesurvival(5y-EFS)was0.80±0.06(medianofobservation4.1years)and0.67±0.19(5.1years)respectively(pgt;0.05).Five-yearoverallsurvival(5y-OS)was0.85±0.05and0.80±0.06respectively(pgt;0.05).ThesituationwithoutmediastinalinvolvementwasafactorforanunfavorableprognosisforT-LBL:5y-EFS–was0.56±0.17vs.0.90±0.05(p=0.036).Sex,age,increasedLDH,sloworfasttherapyresponse,andinvolvementofthecentralnervoussystemorbonemarrowdidnotaffecttheprognosis(pgt;0.05).Conclusions:TheNHL-BFM90and95fornon-B-NHLprotocolsareeffectivetherapeuticregimesforpediatricLBL,andthelong-termresultsobtainedarecomparablewithinternationaldata.
【 授权许可】
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