Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria

Journal of Oral Microbiology

¹  Nezar Noor Al-hebshi² 

[1] osha Perera;Jazan University

关键词: bacteria;    carcinoma;    dysbiosis;    inflammation;    microbiome;    mouth;    squamous cell;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Oralcancer,primarilyoralsquamouscellcarcinoma(OSCC),continuestobeamajorglobalhealthproblemwithhighincidenceandlowsurvivalrates.Whilethemajorriskfactorsforthismalignancy,mostlylifestylerelated,havebeenidentified,around15%oforalcancercasesremainunexplained.Inlightofevidenceimplicatingbacteriaintheaetiologyofsomecancertypes,severalepidemiologicalstudieshavebeenconductedinthelastdecade,employingmethodologiesrangingfromtraditionalculturetechniquesto16SrRNAmetagenomics,toassessthepossibleroleofbacteriainOSCC.Whilethesestudieshavedemonstrateddifferencesinmicrobialcompositionbetweencancerousandhealthytissues,theyhavefailedtoagreeonspecificbacteriaorpatternsoforalmicrobialdysbiosistoimplicateinOSCC.Onthecontrary,someoraltaxa,particularlyPorphyromonasgingivalisandFusobacteriumnucleatum,showstrongoralcarcinogenicpotentialinvitroandinanimalstudies.Bacteriaarethoughttocontributetooralcarcinogenesisviainhibitionofapoptosis,activationofcellproliferation,promotionofcellularinvasion,inductionofchronicinflammation,andproductionofcarcinogens.Thisnarrativereviewprovidesacriticalanalysisofandanupdateontheassociationbetweenbacteriaandoralcarcinogenesisandthepossiblemechanismsunderlyingit.Keywords:bacteria;carcinoma;dysbiosis;inflammation;microbiome;mouth;squamouscell(Published:26September2016)Citation:JournalofOralMicrobiology2016,8:32762-http://dx.doi.org/10.3402/jom.v8.32762

【 授权许可】

Unknown