Journal of Oral Microbiology | |
Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria | |
1  Nezar Noor Al-hebshi2  | |
[1] osha Perera;Jazan University | |
关键词: bacteria; carcinoma; dysbiosis; inflammation; microbiome; mouth; squamous cell; | |
DOI : | |
来源: Co-Action Publishing | |
【 摘 要 】
Oralcancer,primarilyoralsquamouscellcarcinoma(OSCC),continuestobeamajorglobalhealthproblemwithhighincidenceandlowsurvivalrates.Whilethemajorriskfactorsforthismalignancy,mostlylifestylerelated,havebeenidentified,around15%oforalcancercasesremainunexplained.Inlightofevidenceimplicatingbacteriaintheaetiologyofsomecancertypes,severalepidemiologicalstudieshavebeenconductedinthelastdecade,employingmethodologiesrangingfromtraditionalculturetechniquesto16SrRNAmetagenomics,toassessthepossibleroleofbacteriainOSCC.Whilethesestudieshavedemonstrateddifferencesinmicrobialcompositionbetweencancerousandhealthytissues,theyhavefailedtoagreeonspecificbacteriaorpatternsoforalmicrobialdysbiosistoimplicateinOSCC.Onthecontrary,someoraltaxa,particularlyPorphyromonasgingivalisandFusobacteriumnucleatum,showstrongoralcarcinogenicpotentialinvitroandinanimalstudies.Bacteriaarethoughttocontributetooralcarcinogenesisviainhibitionofapoptosis,activationofcellproliferation,promotionofcellularinvasion,inductionofchronicinflammation,andproductionofcarcinogens.Thisnarrativereviewprovidesacriticalanalysisofandanupdateontheassociationbetweenbacteriaandoralcarcinogenesisandthepossiblemechanismsunderlyingit.Keywords:bacteria;carcinoma;dysbiosis;inflammation;microbiome;mouth;squamouscell(Published:26September2016)Citation:JournalofOralMicrobiology2016,8:32762-http://dx.doi.org/10.3402/jom.v8.32762
【 授权许可】
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【 预 览 】
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