The seroprevalence and salivary shedding of herpesviruses in Behcet鈥檚 syndrome and recurrent aphthous stomatitis

Journal of Oral Microbiology

Noha Seoudi¹  Lesley A. Bergmeier¹  Farida Fortune²  Eleni Hagi-Pavli¹  David Bibby³ 

[1] Centre for Clinical and Diagnostic Oral Sciences. Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.;Centre for Clinical and Diagnostic Oral Sciences. Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.;Division of Virology, Barts Health, London, United Kingdom.

关键词: Beh莽et鈥檚 Syndrome;    herpes;    oral mucosa;    saliva;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Objective:ToinvestigatetheseroprevalenceandsalivarysheddingofherpesvirusesinBS.Method:ThelevelsofspecificimmunoglobulinGinsixdifferentherpesvirusesinserumsamplescollectedfrom54BS,28healthycontrols(HC),and7recurrentaphthousstomatitis(RAS)patientswereinvestigated.Salivaryviralloadwasalsoquantifiedforthesevirusesinmatchedsalivasamplesusingquantitativereal-timepolymerasechainreaction.Results:TheBShadlowercytomegalovirus(CMV)IgGlevelincomparisontoHC(p=0.0226)andRAS(p=0.0450).TherewasstatisticallysignificanthighersalivarysheddingofEpstein-Barrvirus(EBV)inBSincomparisontoHC(p=0.0052),butnotRAS(p=0.3318).Conclusions:AhighEBVsheddingwasobservedinbothBSandRASandalowerlevelofCMVIgGwasobservedinBSonly.ThereasonfortheobservedlowerlevelofCMVIgGinBSisnotclear.However,oneexplanationmightbeadefectinthecross-talkbetweeninnateandadaptiveimmuneresponseswhichwassuggestedbyapreviouslydescribeddefectinthetoll-likereceptor1and2heterodimerformationandfunction,thisbeingtheinitialreceptorsensingofCMV.Keywords:Beh莽et#039;ssyndrome;herpes;oralmucosa;saliva(Published:5June2015)Citation:JournalofOralMicrobiology2015,7:27156-http://dx.doi.org/10.3402/jom.v7.27156

【 授权许可】

Unknown