Journal of Oral Microbiology | |
Can oral infection be a risk factor for Alzheimer’s disease? | |
关键词: Alzheimer’s disease; pathogenesis; microorganisms; oral bacteria; direct cause; | |
DOI : | |
来源: Co-Action Publishing | |
【 摘 要 】
Alzheimer’sdisease(AD)isascourgeoflongevitythatwilldrainenormousresourcesfrompublichealthbudgetsinthefuture.Currently,thereisnodiagnosticbiomarkerand/ortreatmentforthismostcommonformofdementiainhumans.ADcanbeofearlyfamilial-onsetorsporadicwithalate-onset.Apartfromthetwomainhallmarks,amyloid-betaandneurofibrillarytangles,inflammationisacharacteristicfeatureofADneuropathology.Inflammationmaybecausedbyalocalcentralnervoussysteminsultand/orbyperipheralinfections.NumerousmicroorganismsaresuspectedinADbrainsrangingfrombacteria(mainlyoralandnon-oralTreponemaspecies),viruses(herpessimplextypeI),andyeasts(Candidaspecies).Acausalrelationshipbetweenperiodontalpathogensandnon-oralTreponemaspeciesofbacteriahasbeenproposedviatheamyloid-betaandinflammatorylinks.Periodontitisconstitutesaperipheraloralinfectionthatcanprovidethebrainwithintactbacteriaandvirulencefactorsandinflammatorymediatorsduetodaily,transientbacteremias.Ifandwhengeneticriskfactorsmeetenvironmentalriskfactorsinthebrain,diseaseisexpressed,inwhichneurocognitionmaybeimpacted,leadingtothedevelopmentofdementia.ToachievethegoaloffindingadiagnosticbiomarkerandpossibleprophylactictreatmentforAD,thereisaninitialneedtosolvetheetiologicalpuzzlecontributingtoitspathogenesis.Thisreviewthereforeaddressesoralinfectionastheplausibleetiologyoflate-onsetAD(LOAD).Keywords:Alzheimer’sdisease;pathogenesis;microorganisms;oralbacteria;directcause(Published:17September2015)Citation:JournalofOralMicrobiology2015,7:29143-http://dx.doi.org/10.3402/jom.v7.29143
【 授权许可】
Unknown
【 预 览 】
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