Can oral infection be a risk factor for Alzheimer’s disease?

Journal of Oral Microbiology

关键词: Alzheimer’s disease;    pathogenesis;    microorganisms;    oral bacteria;    direct cause;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Alzheimer’sdisease(AD)isascourgeoflongevitythatwilldrainenormousresourcesfrompublichealthbudgetsinthefuture.Currently,thereisnodiagnosticbiomarkerand/ortreatmentforthismostcommonformofdementiainhumans.ADcanbeofearlyfamilial-onsetorsporadicwithalate-onset.Apartfromthetwomainhallmarks,amyloid-betaandneurofibrillarytangles,inflammationisacharacteristicfeatureofADneuropathology.Inflammationmaybecausedbyalocalcentralnervoussysteminsultand/orbyperipheralinfections.NumerousmicroorganismsaresuspectedinADbrainsrangingfrombacteria(mainlyoralandnon-oralTreponemaspecies),viruses(herpessimplextypeI),andyeasts(Candidaspecies).Acausalrelationshipbetweenperiodontalpathogensandnon-oralTreponemaspeciesofbacteriahasbeenproposedviatheamyloid-betaandinflammatorylinks.Periodontitisconstitutesaperipheraloralinfectionthatcanprovidethebrainwithintactbacteriaandvirulencefactorsandinflammatorymediatorsduetodaily,transientbacteremias.Ifandwhengeneticriskfactorsmeetenvironmentalriskfactorsinthebrain,diseaseisexpressed,inwhichneurocognitionmaybeimpacted,leadingtothedevelopmentofdementia.ToachievethegoaloffindingadiagnosticbiomarkerandpossibleprophylactictreatmentforAD,thereisaninitialneedtosolvetheetiologicalpuzzlecontributingtoitspathogenesis.Thisreviewthereforeaddressesoralinfectionastheplausibleetiologyoflate-onsetAD(LOAD).Keywords:Alzheimer’sdisease;pathogenesis;microorganisms;oralbacteria;directcause(Published:17September2015)Citation:JournalofOralMicrobiology2015,7:29143-http://dx.doi.org/10.3402/jom.v7.29143

【 授权许可】

Unknown