Salivary concentration of the antimicrobial peptide LL-37 in patients with oral lichen planus

Journal of Oral Microbiology

Sotirios Kalfas¹  Haris Theodoridis²  George Menexes³  Konstantinos Nazer²  Eftichia Kessopoulou²  Sotiria Davidopoulou⁴ 

[1] Professor, Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Greece;Dentist, Dental School, Aristotle University, Thessaloniki;Associate Professor, Department of Labor of Agronomy, School of Agriculture, Aristotle University, Thessaloniki;Phd, Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Greece

关键词: antimicrobial peptide LL-37;    oral lichen planus;    saliva;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Background:TheantimicrobialpeptideLL-37isasignificantmoleculeofinnateimmunityandrecentstudiesindicatethatitplaysanimportantroleinmaintainingoralhealth.Yetlimitedknowledgeexistsonitsroleinoraldiseasesandorallichenplanus(OLP)inparticular.Objective:Thestudyaimedtoexamine:1)thesalivaryconcentrationofLL-37inpatientswithOLPandhealthysubjects,2)therelationbetweenthetype(reticularorerosive)andsizeofOLPlesionsandLL-37concentration,and3)theeffectofthetherapeuticmodalitiesonLL-37levels.Design:Thesalivarypeptideconcentrationinsamplesfrom20patientsand30healthysubjectsatthesameagerangewasdeterminedbyELISA.Results:Despitethewidevariationinpeptideconcentrationfoundinbothgroups,thehealthysubjectsexhibitedsignificantlylowerlevelsthanpatients.Patientswiththeerosiveformhadsignificantlyhigherpeptideconcentrationsthanpatientswiththereticularform.Systemictreatmentwithcorticosteroidsresultedinasignificantdecreaseofthesalivarypeptideconcentration,whileothertreatmentmodalities,suchasadministrationofvitaminsAandEorlocalapplicationofcorticosteroidshadnoeffect.ImprovedclinicalappearanceofthelesionswasfollowedbyadecreaseinthesalivaryLL-37level.Conclusions:SalivaryconcentrationofLL-37correlatestothemanifestationofmucosalesionsinOLPpatients,thehighestlevelsbeingobservedinthemostseverecases.Thisincreaseinpeptidelevelsmayprotectagainstlesioninfectionandpromoteaquickwoundhealing.Keywords:antimicrobialpeptideLL-37;orallichenplanus;saliva(Published:4December2014)Citation:JournalofOralMicrobiology2014,6:26156-http://dx.doi.org/10.3402/jom.v6.26156

【 授权许可】

Unknown