Herpesviruses: latency and reactivation - viral strategies and host response

Journal of Oral Microbiology

Bjørn Grinde¹ 

[1] National Institute of Public Health

关键词: herpes simplex;    Epstein-Barr;    cytomegalovirus;    varicella zoster;    reemergence;    immune defense;    viral pathology;    oral cavity;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

EightmembersoftheHerpesviridaefamilycommonlyinfecthumans,andcloseto100%oftheadultpopulationisinfectedwithatleastoneofthese.Thefivethatcausethemosthealthconcernsare:herpessimplexvirus(HSV)type1and2,EpsteinBarrvirus(EBV),cytomegalovirus(CMV),andvaricellazostervirus(VZV).Inaddition,therearehumanherpesvirus(HHV)types68.Thereviewstartsbyintroducingpossibleviralstrategiesingeneral.Theparticularbiologyandhostrelationshipofthevarioushumanherpesviruses,includingtheirpathology,areexaminedsubsequently.Factorsthatcontributetothemaintenanceoflatencyandreactivationofviralreplicationarediscussed.Therewillbespecialreferencetohowthesevirusesexploitandcontributetopathologyintheoralcavity.Reactivationdoesnotnecessarilyimplyclinicalsymptoms,asreflectedintheasymptomaticsheddingofEBVandCMVfromoralmucosa.Theimmuneresponseandthelevelofviraloutputarebothimportanttotheconsequencesexperienced.Keywords:herpessimplex;EpsteinBarr;cytomegalovirus;varicellazoster;reemergence;immunedefense;viralpathology;oralcavity(Published:25October2013)Citation:JournalofOralMicrobiology2013,5:22766-http://dx.doi.org/10.3402/jom.v5i0.22766

【 授权许可】

Unknown