Journal of Oral Microbiology | |
Tracking of plasma antibodies againstAggregatibacter actinomycetemcomitansandPorphyromonas gingivalisduring 15 years | |
Georg Alfthan2  Laura Lakio1  Susanna Paju1  Kåre Buhlin1  Pirkko J. Pussinen1  Johanna Antinheimo1  | |
[1] Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki;Biomarker Laboratory, Department of Health and Functional Capacity, National Public Health Institute, Helsinki, Finland | |
关键词: Aggregatibacter actinomycetemcomitans; longitudinal studies; periodontitis; plasma; Oral infections; Porphyromonas gingivalis; saliva; | |
DOI : | |
来源: Co-Action Publishing | |
【 摘 要 】
Background:Plasmaantibodymeasurementsofantibodylevelstoperiodontalpathogensmaybeusedtosupportdiagnosis,diseaseactivity,classification,andprognosisofperiodontitis.Objective:Theaimofthisstudywastoinvestigatethelong-termstabilityofplasmaantibodylevelsagainstAggregatibacteractinomycetemcomitansandPorphyromonasgingivalis.Design:PlasmaimmunoglobulinG(IgG)antibodylevelsagainstthepathogenswereanalyzedannuallyduring15yearsfrom21voluntarysubjects,whoseperiodontalstatuswasnotknownatthepointofselection.Thetotalnumberofplasmasampleswas315.Inconnectionofthelastsampling,theclinicalandradiographicperiodontalstatuswasexamined.Pooledbacterialsamplesfromperiodontalpockets,aswellassalivarysampleswerecollectedforA.actinomycetemcomitansandP.gingivalisdetection,andantibodydeterminations,respectively.Accordingtotheclinicalstatus,sixsubjectshadperiodontitis,whereas15didnot.Results:PlasmaIgG-classantibodylevelstoperiodontalpathogensremainedextremelystableduringthe15-yearperiodandnosignificant(pamp;gt;0.05)intra-individualvariationswereobserved.Retrospectively,theaverageplasmaIgGantibodylevelsagainstA.actinomycetemcomitansandP.gingivaliswere1.6-2.3(pamp;lt;0.05)and1.4-1.7(pamp;lt;0.05)foldhigherinthesubjectswithperiodontitisthanthosewithout,respectively,duringthewhole15-yeartracking.Asexpected,atthetimeoftheperiodontalexaminationtheplasmaandsalivaryIgGantibodylevelswereassociatedbothwithperiodontitisandbacterium-positivity.Conclusions:PlasmaIgGlevelsagainstA.actinomycetemcomitansandP.gingivalisareextremelystableduring15yearsbothinsubjectswithandwithoutperiodontitis.Keywords:Aggregatibacteractinomycetemcomitans;longitudinalstudies;periodontitis;plasma;oralinfections;Porphyromonasgingivalis;saliva(Published:3August2009)Citation:JournalofOralMicrobiology2009.DOI:10.3402/jom.v1i0.1979
【 授权许可】
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【 预 览 】
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