Tracking of plasma antibodies againstAggregatibacter actinomycetemcomitansandPorphyromonas gingivalisduring 15 years

Journal of Oral Microbiology

Georg Alfthan²  Laura Lakio¹  Susanna Paju¹  Kåre Buhlin¹  Pirkko J. Pussinen¹  Johanna Antinheimo¹ 

[1] Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki;Biomarker Laboratory, Department of Health and Functional Capacity, National Public Health Institute, Helsinki, Finland

关键词: Aggregatibacter actinomycetemcomitans;    longitudinal studies;    periodontitis;    plasma;    Oral infections;    Porphyromonas gingivalis;    saliva;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Background:Plasmaantibodymeasurementsofantibodylevelstoperiodontalpathogensmaybeusedtosupportdiagnosis,diseaseactivity,classification,andprognosisofperiodontitis.Objective:Theaimofthisstudywastoinvestigatethelong-termstabilityofplasmaantibodylevelsagainstAggregatibacteractinomycetemcomitansandPorphyromonasgingivalis.Design:PlasmaimmunoglobulinG(IgG)antibodylevelsagainstthepathogenswereanalyzedannuallyduring15yearsfrom21voluntarysubjects,whoseperiodontalstatuswasnotknownatthepointofselection.Thetotalnumberofplasmasampleswas315.Inconnectionofthelastsampling,theclinicalandradiographicperiodontalstatuswasexamined.Pooledbacterialsamplesfromperiodontalpockets,aswellassalivarysampleswerecollectedforA.actinomycetemcomitansandP.gingivalisdetection,andantibodydeterminations,respectively.Accordingtotheclinicalstatus,sixsubjectshadperiodontitis,whereas15didnot.Results:PlasmaIgG-classantibodylevelstoperiodontalpathogensremainedextremelystableduringthe15-yearperiodandnosignificant(pamp;gt;0.05)intra-individualvariationswereobserved.Retrospectively,theaverageplasmaIgGantibodylevelsagainstA.actinomycetemcomitansandP.gingivaliswere1.6-2.3(pamp;lt;0.05)and1.4-1.7(pamp;lt;0.05)foldhigherinthesubjectswithperiodontitisthanthosewithout,respectively,duringthewhole15-yeartracking.Asexpected,atthetimeoftheperiodontalexaminationtheplasmaandsalivaryIgGantibodylevelswereassociatedbothwithperiodontitisandbacterium-positivity.Conclusions:PlasmaIgGlevelsagainstA.actinomycetemcomitansandP.gingivalisareextremelystableduring15yearsbothinsubjectswithandwithoutperiodontitis.Keywords:Aggregatibacteractinomycetemcomitans;longitudinalstudies;periodontitis;plasma;oralinfections;Porphyromonasgingivalis;saliva(Published:3August2009)Citation:JournalofOralMicrobiology2009.DOI:10.3402/jom.v1i0.1979

【 授权许可】

Unknown