The effect of topical capsaicin-induced sensitization on heat-evoked cutaneous vasomotor responses

International Journal of Physiology, Pathophysiology and Pharmacology

Parisa Gazerani¹  Thomas A Nielsen¹  Larissa Bittencourt da Silva¹  Lars Arendt-Nielsen¹ 

[1] Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark

关键词: Neurogenic inflammation;    vasomotor response;    thermal stimulation;    sensitization;    capsaicin;    cutaneous;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Brief,localized,cutaneous,non-painfulthermalstimulicanevokeatransientvasomotorresponse,causingincreasedcutaneousbloodflowandelevatedskintemperature.Theaimsofthisstudyweretoinvestigate1)ifcutaneoussensitizationbytopicalapplicationofcapsaicin(TRPV1receptoragonist)canfacilitatethesize,durationandspatialextentofthisvasomotorresponseand2)ifmalesandfemalesresponddifferently.Thermalpulses(43#176;Cfor60seconds)wereappliedonleft/rightvolarforearmsof15age-matchedmalesandfemales.Skintemperatureandcutaneousbloodflowweremeasured1,5,10,15,and30minutesafterheatapplicationbeforeandaftertopicalcapsaicin(1%,30minapplication)withcontralateralarmservingasthecontrol.Recordingsweremadefromtheregionofinterestatdistancesof2,4,6,8,and10cmfromthecapsaicinapplicationsite.Sensitizationsignificantlyenhancedskintemperatureforupto30minandcomparedwithnon-sensitizedskinat10min.Femalesshowedthestrongestresponseaftersensitization,buttheresponselastedlongerandspreadmorewidelyinmales.Thebloodflowresponsesweresignificantlylongeraftercapsaicin(from5to30minutesafterthermalapplication).Thisincreasedbloodflowextendedoutsidethetreatedareaupto10minafterstimulation.Aftersensitization,theareaunderthebloodflowresponsecurvesshowedsignificantlystrongerresponsesinfemales,spreading4cmoutsidethestimulationsite.Cutaneoussensitizingcausedprolongedandspatiallyexpandedvasomotorresponsestostandardizedthermalstimulationwithsexspecificdifferences.(IJPPP1305003).

【 授权许可】

Unknown