Antioxidant activity of simvastatin prevents L-arginine-induced acute toxicity of pancreas

International Journal of Physiology, Pathophysiology and Pharmacology

Lina A Fatlawi¹  Ismail I Matalka¹  Nizar M Mhaidat¹ 

[1] Department of pathology, Jordan University of Science and Technology, Irbid 22110, Jordan; Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan

关键词: L-arginine;    acute pancreatitis;    simvastatin;    lipid peroxidation;    antioxidant enzymes;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

L-arginineisasemi-essentialaminoacidthatfoundnaturallyinfood.IthasbeenshownthatadministrationoflargedosesofL-argininecaninduceacutepancreatitis.Inthepresentstudy,weevaluatedifsimvastatin,a3-hydroxy-methylglutarylcoenzymeAreductase(HMG-CoAreductase)inhibitor,mightpreventacutepancreatitisinducedbyL-arginine.ThirtymaleWistarratswererandomlyallocatedtofivegroups.Groupswere:DMSO,saline,simvastatin,L-arginine,andsimvastatinwithL-arginine.Twentyfourhoursafterthelastdose,ratsweresacrificedandtheirbloodwascollectedfromheartforbiochemicalanalysis.Pancreatictissueswereobtainedforanalysisofglutathioneperoxidase(GPx),glutathiones-transferase(GST),lipidperoxidelevels(MDA)andhistologyanalysiswasexaminedforpancreas.ResultsindicatedthattreatmentwithsimvastatinsignificantlyenhancedlevelsofGPxandGSTanddecreasedlipidperoxidelevelsinducedbyL-argininecomparedtothevehicle.Moreover,histopathologicalanalysisfurtherconfirmedthatadministrationofsimvastatinrelativelypreventedpancreaticacinarcelldamagecomparedtothoseanimalsreceivedL-argininealone.ThesefindingspointedouttheprotectiveroleofsimvastatinagainstacutepancreatitisinducedbyhighdosesofL-arginine.(IJPPP1301003).

【 授权许可】

Unknown