Serotonergic modulation of Neural activities in the

International Journal of Physiology, Pathophysiology and Pharmacology

Saobo Lei¹ 

[1] Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University

关键词: Glutamate;    GABA;    synaptic transmission;    epilepsy;    neurotransmitter;    G-protein coupled receptor;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Theentorhinalcortex(EC)isconsideredasthegatetocontroltheflowofinformationintoandoutofthehippocampus.TheECisimportantfornumerousphysiologicalfunctionssuchasemotionalcontrol,learningandmemoryandpathologicaldisordersincludingAlzheimer#8217;sdisease,schizophreniaandtemporallobeepilepsy.Serotoninisaclassicalneurotransmitterwhichmaymodifythesephysiologicalfunctionsandpathologyofneurologicaldiseases.TheECreceivesprofuseserotonergicinnervationsfromtheraphenucleiinthebrainstemandexpresseshighdensityofserotonergicreceptorsincluding5-HT1A,5-HT1D,5-HT1E,5-HT2A,5-HT3and5-HT6.TheprominentinnervationbyserotonergicneuronsandthedenseexpressionofserotonergicreceptorsintheECsuggestthatserotoninisamajormodulatorinthisbrainregion.SerotoninexertsinhibitoryeffectsintheEC.Serotoninhyperpolarizesentorhinalneuronsandinhibitstheexcitatorysynaptictransmissionviaactivationof5-HT1AreceptorsbutfacilitatesGABAreleaseviaactivationof5-HT2Areceptors.Both5-HT1Aand5-HT2Areceptorsarerequiredforserotonin-inducedinhibitionofepileptiformactivityalthough5-HT3receptorsmaybeinvolvedinserotonin-mediatedinhibitionofacetylcholinereleaseintheEC.Furthermore,thefunctionsofserotoninintheECmaybeimplicatedinParkinson#8217;sdisease,Alzheimer#8217;sdiseaseanddepression.Thus,understandingtherolesofserotonergicmodulationintheECisofmajorclinicalimportance.Here,IreviewrecentfindingsconcerningtheeffectsofserotoninonneuralcircuitryactivityintheEC.(IJPPP1211003).

【 授权许可】

Unknown