Roles of caveolin-1 on anoikis resistance in non small cell lung cancer

International Journal of Physiology, Pathophysiology and Pharmacology

Pithi Chanvorachote¹  Preedakorn Chunhacha¹ 

[1] Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, and Cell-based Drug and Health Products Development Research Unit, Chulalongkorn, University Bangkok, 10330, Thailand

关键词: Caveolin-1 (Cav-1);    anoikis resistance;    Non Small Cell Lung Cancer (NSCLC);    cancer therapy;    apoptosis resistance;    metastasis;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Advancetherapieswhicheffectivelyreducemortalityinlungcancerpatientsbecomeaglobalhealthchallengenowadays.Sufficientknowledgeregardingcellularandmolecularbasisofcancerprogressionandmetastasiswouldpossiblyhelpinthedevelopmentofnovelandeffectivestrategiesforthetreatmentofthisdisease.Thisreviewfocusesontheinformationregardingtheroleandmechanismofcaveolin-1(Cav-1)proteinonanoikisinNonSmallCellLungCancer(NSCLC).NSCLCaccountsofapproximately80%ofalldiagnosedlungcancercaseswhichpatientsfrequentlypresentedwithmetastaticdisease.Likeothercancers,caveolin-1(Cav-1)hasbeenshowntoplayanimportantroleinregulatingcancer-cellsbehaviorsincludingapoptosisresistanceandmetastasis.Eventhoughfurtherinvestigationsaswellasinvivoexperimentsarerequired,thesedataareofgreatinterestandmaybebeneficialtothedevelopmentoflungcancertherapy.(IJPPP1207001).

【 授权许可】

Unknown