Inhibitory effects of salviae miltiorrhizae radix (danshen) and puerariae lobatae radix (gegen) in carbachol-induced rat detrusor smooth muscle contractility

International Journal of Physiology, Pathophysiology and Pharmacology

Johnny Chi Man Koon¹  Clara Bik San Lau¹  Willmann Liang¹  Ivy Wen Jia Teong¹  Ping Chung Leung¹  Kwok Pui Fung¹ 

[1] School of Biological Sciences, College of Science, Nanyang Technological University, Singapore; Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Hong Kong, China; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China

关键词: Detrusor smooth muscle;    contractility;    danshen;    gegen;    Chinese medicine;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Bothdanshen(D)andgegen(G)haveprovenrelaxanteffectsonvascularsmoothmuscle,thustheirpotentialbladderinhibitoryeffectshaveimpendinginterestsinurology.TheaimofthisstudywastodemonstratethenoveleffectsofDandGondetrusorsmoothmusclecontractility.Urothelium-intact(+UE)andurothelium-denuded(#8211;UE)detrusorstripswereisolatedfromtherat.Isometrictensionwasmeasuredusingamyographsystem.Carbachol(CCh)wasusedtopre-contractthedetrusorstripspriortostepwiserelaxationbyaddingextractsofD,G,andaDG(7:3)formulation.Tonicrelaxationlevelandphasiccontractileactivityundertheherbaltreatmentswereanalyzed.Therewasnodifferenceintheherbaleffectsbetween+UEand#8211;UEstrips.DaloneinducedamuchsmallerrelaxationthanGaloneorDG.GalonealsosuppressedphasicamplitudebutnotphasicfrequencywhileDGsuppressedbothparameters.DandGactedsynergisticallytoyieldtheobservedeffectsondetrusorsmoothmuscle.ThefindingsshowedthattheDGformulationwereabletorelaxthedetrusoraswellassuppressphasiccontractions,bothactionsimportantinmaintainingnormalbladderfillingandurinestorageprocesses.HenceDGmayhavenewapplicationinthemanagementofbladderdisorders.(IJPPP1201001).

【 授权许可】

Unknown