The roles of microRNAs in tumorigenesis and angiogenesis

International Journal of Physiology, Pathophysiology and Pharmacology

Zhi-Gang Xiong¹  Minghua Li¹ 

[1] Department of Psychology, Washington State University, Vancouver, WA, USA. Neuroscience Institute, Morehouse

关键词: Ion channels;    cancer;    therapeutic targets;    voltage-gated K+;    Na+;    Ca2+ channels;    TRP channels;    and;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Cancerisaleadingcauseofdeathintheworld.Conventionaltreatmentshaveseveresideeffectsandlowsurvivalrate.Itisimportanttodiscovernewtargetsandtherapeuticstrategiestoimprovetheclinicaloutcomesofcancerpatients.Ionchannelsarespecializedmembraneproteinsthatplayimportantrolesinvariousphysiologicalprocesses.Recentstudieshaveshownthatabnormalexpressionand/oractivityofanumberofionchannelse.g.voltage-gatedK+,Na+,Ca2+channels,TRPchannels,andepithelialNa+/degenerinfamilyofionchannels,areinvolvedinthegrowth/proliferation,migrationand/orinvasionofcancercells.Inthisreview,wesummarizethepresentknowledgeabouttherolesofdifferentionchannelsinthedevelopmentofcancer(IJPPP1106003).

【 授权许可】

Unknown