Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System

Chemical and biochemical engineering quarterly

T. Hong-Ngan Tran¹  C. Dang¹  C. Im¹  T. . Nguyen¹  C. Nguyen¹ 

关键词: nanoparticle;    nanocarrier;    drug delivery;    β-cyclodextrin;    alginate;    ketoprofen;    drug release;   

DOI  :  10.15255/CABEQ.2014.2092

来源: Croatian Society of Chemical Engineers

【 摘 要 】

Abstract The aim of this work was to study a novel nanoparticle system formed from alginate and β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginate gel and β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent. Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h.

【 授权许可】

Unknown