Chemical and biochemical engineering quarterly | |
Nanoencapsulation of Drug-loaded Lipid by Temperature-induced Phase Transition | |
J. Lee1  H. Lee1  K. S. Oh1  S. H. Yuk1  J. Y. Kim1  E. J. Koo1  E. H. Lee1  | |
关键词: Nanoencapsulation; pluronic; temperature – induced phase transition; solubility; | |
DOI : | |
来源: Croatian Society of Chemical Engineers | |
【 摘 要 】
Abstract Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a drug delivery system, the release pattern of model drugs was observed.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912090769099ZK.pdf | 738KB | download |