Nanoencapsulation of Drug-loaded Lipid by Temperature-induced Phase Transition

Chemical and biochemical engineering quarterly

J. Lee¹  H. Lee¹  K. S. Oh¹  S. H. Yuk¹  J. Y. Kim¹  E. J. Koo¹  E. H. Lee¹ 

关键词: Nanoencapsulation;    pluronic;    temperature – induced phase transition;    solubility;   

DOI  :  

来源: Croatian Society of Chemical Engineers

【 摘 要 】

Abstract Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a drug delivery system, the release pattern of model drugs was observed.

【 授权许可】

Unknown