A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites

Developmental Biology

Fiona C. Wardle¹  Leila Jahangiri¹  Andrew C. Nelson¹ 

DOI  :  10.1016/j.ydbio.2012.07.002

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Somitesformbyaniterativeprocessfromunsegmented,presomiticmesoderm(PSM).Notchpathwaycomponents,suchasdeltaC(dlc)havebeenshowntoplayaroleinthisprocess,whiletheT-boxtranscriptionfactorsNtlaandTbx16regulatesomiteformationupstreamofthisbycontrollingsupplyandmovementofcellsintothePSMduringgastrulationandtailbudoutgrowth.Inthiswork,wereportthatNtlaandTbx16playamoreexplicitroleinsegmentationbydirectlyregulatingdlcexpression.Inadditionwedescribeacis-regulatorymodule(CRM)upstreamofdlcthatdrivesexpressionofareporterinthetailbud,PSMandsomitesduringsomitogenesis.ThisCRMisboundbybothNtlaandTbx16ataclusterofT-boxbindingsites,whicharerequiredincombinationforactivationoftheCRM.

【 授权许可】

Unknown   

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