Threshold-specific requirements for Bmp4 in mandibular development

Developmental Biology

Xiaoxia Sun²  James F. Martin²  Jennifer Selever²  Deepa Murali¹  Sean M. Brugger³  Lijiang Ma²  Yasuhide Furuta¹  Wei Liu²  Robert J. Schwartz²  Robert Maxson³ 

[1] Program in Genes and Development, University of Texas, Graduate School of Biomedical Sciences at Houston, and Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA;Alkek Institute of Biosciences and Technology, Texas A&M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA;Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA

DOI  :  10.1016/j.ydbio.2005.04.019

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Mandibulardevelopmentisregulatedbyaninterplaybetweenaspecifiedbranchialarchectodermandaplasticmesenchyme.Moreover,signalingfromthepharyngealendodermhasbeenshowntobeimportantformandibularmorphogenesis.Togaininsightintothemechanismsregulatingmandibularpattern,itisimportanttoinvestigatethefunctionoftheepithelial-derivedsignals.Bmp4isexpressedinbothdistal,mandibulararchectodermandpharyngealendoderm.Here,weshowthatdeletionofBmp4inthemandibularectodermandtoalesserextentinthepharyngealendoderm,resultedinseveredefectsinmandibulardevelopment.Furthermore,ourdatauncovereddifferentBmp4thresholdsforexpressionoftheBmp-dependentMsx1andMsx2genesinmandibularmesenchyme.WealsofoundthatectodermalFgf8expressionwasbothactivatedandrepressedbyBmp4inadosage-dependentfashionindicatinganovelBmp4functioninthreshold-specificregulationofFgf8transcription.Lastly,weprovideevidencethatPrxhomeoboxgenesrepressexpressionofanMsx2transgene,previouslyshowntobeBmp4-responsive,revealingamechanismfordifferentialregulationofMsx1andMsx2byBmpsignaling.

【 授权许可】

Unknown   

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