Early Steps in the Formation of Neural Tissue in Ascidian Embryos

Developmental Biology

C. Hudson¹  V. Bertrand¹  P. Lemaire¹ 

[1] Institut de Biologie du Développement de Marseille, Laboratoire de Génétique et Physiologie du Développement, CNRS Université de la Méditerranée, Case 907, Campus de Luminy, F-13288, Marseille, France

关键词: ascidians;    chordates;    evolution;    nervous system;    neural induction;    embryo;    development;    neurone;    Otx;    BMP;    FGF;    proteases;    CNS;    PNS;    placodes;    neural crest;   

DOI  :  10.1006/dbio.2002.0861

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Ascidiansaresimpleinvertebratechordateswhoselineagedivergedfromthatofvertebratesatthebaseofthechordatetree.Theirlarvaedisplayatypicalchordatebodyplan,butarecomposedofaremarkablysmallnumberofcells.Ascidiansdevelopwithaninvariantcelllineage,andtheirembryoscanbeeasilyexperimentallymanipulatedduringthecleavagestages.Theirlarvalnervoussystemisorganisedinasimilarwayasinvertebratesbutiscomposedoflessthan130neuronesandaround230glialcells.Thisremarkablesimplicityoffersanopportunitytounderstand,atthecellularandmolecularlevels,theontogenyandfunctionofeachneuralcell.Here,wefirstreviewtheorganisationoftheascidiannervoussystemanditslineage.Wethenfocusonthecurrentunderstandingoftheprocessesofneuralspecificationandpatterningbeforeandduringgastrulation.Wediscusstheseadvancesinthecontextofwhatiscurrentlyknowninvertebrates.

【 授权许可】

Unknown