Developmental Biology | |
The Dorsal–Ventral Axis of the Neural Retina Is Divided into Multiple Domains of Restricted Gene Expression Which Exhibit Features of Lineage Compartments | |
Constance L. Cepko1  Maureen A. Peters1  | |
[1] Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, Massachusetts, 02115 | |
关键词: retina; patterning; compartments; Tbx5; Vax; Bmp4; ALDH; retinoic acid; Eph; | |
DOI : 10.1006/dbio.2002.0791 | |
学科分类:生物科学(综合) | |
来源: Academic Press | |
【 摘 要 】
Theneuralretinaisacomplexsensorystructuredesignedtoreceive,integrate,andtransmitvisualinformation.Animportantaspectofretinaldevelopmentistheestablishmentofpatternalongthedorsal–ventral(D-V)andanterior–posterior(A-P)axes.Therecentidentificationandfunctionalcharacterizationofadorsal-specificandaventral-specifictranscriptionfactorsuggestedthattheD-Vaxisisdividedintotwodomains.ThisstudycharacterizestheexpressionpatternsoftheseandotherD-Vmarkers,andestablishesthattheretinaissubdividedintoatleastfourdomainsofgeneexpressionalongthisaxis.ThecompositionandspatialrelationoftheseexpressiondomainsaltersourmodelofD-Vpatterning,suggestingmorecomplexityinthewaythattheretinaispatternedthanwaspreviouslyrecognized.Asdomainsofgeneexpressionwithindevelopingtissuessometimescomprisecompartmentswhosebordersarenotcrossedbyclonallyrelatedcells,weperformedaretrovirallineagestudy.Astrongpreferenceforcellstoremainintheiroriginaldomainofgeneexpressionwasobserved,suggestingthattheseborderscomprisedevelopmentalcompartments.
【 授权许可】
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