The Dorsal–Ventral Axis of the Neural Retina Is Divided into Multiple Domains of Restricted Gene Expression Which Exhibit Features of Lineage Compartments

Developmental Biology

Constance L. Cepko¹  Maureen A. Peters¹ 

[1] Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, Massachusetts, 02115

关键词: retina;    patterning;    compartments;    Tbx5;    Vax;    Bmp4;    ALDH;    retinoic acid;    Eph;   

DOI  :  10.1006/dbio.2002.0791

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Theneuralretinaisacomplexsensorystructuredesignedtoreceive,integrate,andtransmitvisualinformation.Animportantaspectofretinaldevelopmentistheestablishmentofpatternalongthedorsal–ventral(D-V)andanterior–posterior(A-P)axes.Therecentidentificationandfunctionalcharacterizationofadorsal-specificandaventral-specifictranscriptionfactorsuggestedthattheD-Vaxisisdividedintotwodomains.ThisstudycharacterizestheexpressionpatternsoftheseandotherD-Vmarkers,andestablishesthattheretinaissubdividedintoatleastfourdomainsofgeneexpressionalongthisaxis.ThecompositionandspatialrelationoftheseexpressiondomainsaltersourmodelofD-Vpatterning,suggestingmorecomplexityinthewaythattheretinaispatternedthanwaspreviouslyrecognized.Asdomainsofgeneexpressionwithindevelopingtissuessometimescomprisecompartmentswhosebordersarenotcrossedbyclonallyrelatedcells,weperformedaretrovirallineagestudy.Astrongpreferenceforcellstoremainintheiroriginaldomainofgeneexpressionwasobserved,suggestingthattheseborderscomprisedevelopmentalcompartments.

【 授权许可】

Unknown