Dorsal Gradient Networks in the Drosophila Embryo

Developmental Biology

Michael Levine¹  Angelike Stathopoulos¹ 

[1] Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, California, 94720-3204

关键词: Dorsal;    gradient;    Drosophila embryo;    gene network;   

DOI  :  10.1006/dbio.2002.0652

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Here,wedescribeoneofthemajormaternalregulatorygradients,Dorsal,andthresholdoutputsofgeneexpressionthatresultfromthegradeddistributionofthistranscriptionfactor.TheanalysisofalargenumberofauthenticandsynthetictargetgenessuggeststhattheDorsalgradientdirectlyspecifiesatleastfour,andpossiblyasmanyasseven,differentthresholdsofgeneactivityandtissuedifferentiation.Thesethresholdsinitiatethedifferentiationofthethreeprimaryembryonictissues:themesoderm,neurogenicectoderm,anddorsalectoderm.Moreover,primaryreadoutsoftheDorsalgradientcreateasymmetriesthatsubdivideeachtissueintomultiplecelltypesduringgastrulation.Dorsalpatterningthresholdsrepresenttheculminationofoneofthemostcompletegeneregulationnetworkknownindevelopment,whichbeginswiththeasymmetricpositioningoftheoocytenucleuswithintheeggchamberandleadstothelocalizedactivationoftheToll-Dorsalsignalingpathwayinventralregionsoftheearlyembryo.

【 授权许可】

Unknown