Sonic hedgehog Is Required Early in Pancreatic Islet Development

Developmental Biology

Jennifer B. Moss¹  Jennifer L. Sbrogna¹  Philip J. diIorio¹  Rolf O. Karlstrom¹  Larry G. Moss¹ 

[1] Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, 02111

关键词: pancreas;    islet;    zebrafish;    hedgehog;    insulin;   

DOI  :  10.1006/dbio.2002.0573

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Pancreaticorganogenesisreliesonacomplexinterplayofcell-autonomousandextracellularsignals.Wedemonstratethatthemorphogensonichedgehog(Shh)isrequiredforpancreaticdevelopmentinzebrafish.GeneticmutantsofShhanditssignalingpathwayestablishthisdependenceasspecifictoendocrine,butnotexocrine,pancreas.Usingcyclopaminetoinhibithedgehogsignaling,weshowthattransientShhsignalingisnecessaryduringgastrulationforsubsequentdifferentiationofendodermintoislettissue.Asecondhedgehog-dependentactivityoccurringlaterindevelopmentwasalsoidentifiedandmaybeanalogoustotheknownactionofShhingutendodermtodirectlocalizationofpancreaticdevelopment.TheearlyactionofShhmaybepartofamoregeneralprocessallowingneuroendocrinecellstooriginateinnonneuroectodermallyderivedtissues.

【 授权许可】

Unknown