Simulation Model of Trabecular Bone Remodeling Considering Effects of Osteocyte Apoptosis and Targeted Remodeling

Journal of Biomechanical Science and Engineering

Jiyean KWON¹  Masao TANAKA¹  Hisashi NAITO¹  Takeshi MATSUMOTO¹ 

[1] Department of Mechanical Science and Bioengineering, Osaka University

关键词: Computational Biomechanics;    Remodeling Turnover;    Osteocyte Apoptosis;    Targeted Remodeling;   

DOI  :  10.1299/jbse.5.539

来源: Japan Society of Mechanical Engineers

【 摘 要 】

References(19)Cited-By(3)Bone structure is renewed or restructured in part by a load-dependent remodeling. In this study, a mathematical model of bone surface remodeling over a wide range of strain was established. We assumed that in a low strain range, bone resorption occurs at an accelerated rate with strain decrease owing to low strain-induced osteocyte apoptosis, and that in a high strain range, bone formation occurs at an accelerated rate with strain increase (targeted remodeling). In a physiological strain range, bone formation or resorption was assumed to occur stochastically according to the degree of local stress non-uniformity. The utility of the present model was examined through three-dimensional numerical simulation of femoral trabecular architecture.

【 授权许可】

Unknown