Green synthesis of graphene nanosheets and their in vitro cytotoxicity against human prostate cancer (DU 145) cell lines

Nanomaterials and Nanotechnology

Xiaolin Xu¹  Zhan-song Zhou¹  Jianjun Yu¹  Feng Liu¹  Xin Zhu¹  Jizhong Jin¹  Lintao Liu¹  Zhi-wen Chen¹  Yi Zhi¹ 

关键词: Citrullus colocynthis;    cytotoxicity;    oxidized polyphenols;    RGO;   

DOI  :  10.1177/1847980417702794

来源: InTech

【 摘 要 】

A simple and green approach for the synthesis of polyphenol-functionalized reduced graphene oxide nanosheets is demonstrated, using leaf extract of Citrullus colocynthis as a deoxygenating agent. The C. colocynthis polyphenols also play a significant role as a stabilizing agent, preventing agglomeration of reduced graphene oxide nanosheets. Cytotoxicity tests showed that the both graphene oxide and Citrullus colocynthis polyphenol-stabilized reduced graphene oxide were toxic to DU145 cells; the cytotoxicity was dose dependent. Hence, C. colocynthis–mediated reduced graphene oxide may be an ideal anticancer material for biological study applications.

【 授权许可】

Unknown