pH-Responsive Vesicles with Tunable Membrane Permeability and Hydrodynamic Diameters from a Cross-Linkable Amphiphilic Block Copolymer

Nanomaterials and Nanotechnology

Jianglei Qin¹  Ruixue Chang¹  Yong Wang¹  Yuelan Tian¹ 

关键词: Block Copolymer;    Self-assembly;    pH Responsive;    Vesicles;    PDEA;   

DOI  :  10.5772/62151

来源: InTech

【 摘 要 】

A series of cross-linked, pH responsive vesicles with tunable diameters were prepared by self-assembly of poly (ethyleneoxide)-b-poly [2-(diethylamino) ethyl methacrylate-co-glycidyl methacrylate, PEO-b-P(DEA-co-GMA)] in a THF/water mixture. The copolymers were synthesized by the random copolymerization of DEA and GMA, initiated by PEO-Br. With an epoxy group and a tertiary amine in its structure, self-catalysed cross-linking was triggered easily by mild heating. The vesicles showed pH responsiveness as characterized by DLS, and tunable permeability can be understood accordingly. As the pH of the solvent changed from 9.8 to 7.4, the diameters of the vesicles increased. It was observed that the diameters at pH = 6.0 were comparable to those at pH = 7.4. This alteration may have occurred because of the protonation of the PDEA segment. This particular property has great potential and many applications, since most drug-loading and controlled-release studies are conducted within this pH range.

【 授权许可】

Unknown