Dual Drug Release of Triamterene and Aminophylline from Poly (N-Isopropylacrylamide) Hydrogels

Nanomaterials and Nanotechnology

Emilio Castro¹  Issa Katime¹  Víctor Mosquera¹ 

关键词: Drug delivery systems;    hydrogels;    polyamides;    diffusion;    UV-Vis spectroscopy;   

DOI  :  10.5772/50338

来源: InTech

【 摘 要 】

We used temperature-sensitive poly(N-isopropylacrylamide) hydrogels as drug delivery systems, so changes in body temperature induced by pathogens could act like external stimuli to activate controlled release of the drugs incorporated in the hydrogel. In the distilled water combined release studies, we chose two model drugs: aminophylline and triamterene. The amount of drug released was measured by UV-Vis spectroscopy following the evolution of the absorption peaks of aminophylline (271 nm) and triamterene (365 nm). The maximum release time was greater for triamterene than for aminophylline at 37 °C, so these time-release profiles enabled the active ingredients to work over different periods of time. By increasing molar mass or solubility of the drug, we observed that the diffusion coefficient decreased. On the contrary, increasing hydrophobicity of the drug leads to a diffusion coefficient increase. The evolution of pore size distribution of hydrogels during loading and releasing was measured by quasi-el...

【 授权许可】

Unknown