Enhanced Lipid Peroxidation in Epileptics With Null Genotype of Glutathione S-Transferase M1 and Intractable Seizure

The Japanese Journal of Pharmacology

Ching-Shan Tsai¹  Chin-San Liu¹ 

[1]Department of Neurology & Neuroscience, Changhua Christian Hospital

关键词: Glutathione S-transferase genotype;    Epilepsy;    Lipid peroxidation;   

DOI  :  10.1254/jjp.90.291

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(3)Null genotype of glutathione S-transferase class μ (GSTM1(−)) and the plasma level of malondialdehyde (MDA) were determined in normal subjects, epileptics with good seizure control and epileptics with intractable seizure. The frequency of GSTM1(−) of the epileptics with intractable seizure was significantly higher than that of the group with good seizure control and that of the normal subjects. The average plasma level of MDA of the patients with GSTM1(−) genotype was higher than that of the subjects with GSTM1(+) in either the normal or epileptic group. Thus, the GSTM1(−) genotype may be one of the genetic factors involved in the response to anticonvulsant therapy.

【 授权许可】

Unknown