Effects of Minoxidil on Ischemia-Induced Mechanical and Metabolic Dysfunction in Dog Myocardium

The Japanese Journal of Pharmacology

Seiichiro Kano¹  Kazuo Ichihara¹  Kumi Satoh¹  Shigeru Kaneta¹  Atsuko Yamamoto¹  Kenichi Ichinosawa¹ 

[1] Department of Pharmacology, Hokkaido College of Pharmacy

关键词: Minoxidil;    Ischemia;    Reperfusion;    KATP channel;    ATP;   

DOI  :  10.1254/jjp.90.173

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(27)Cited-By(3)Effects of minoxidil on ischemia-induced myocardial mechanical and metabolic dysfunction were examined in anesthetized open-chest dogs. A regional portion of the left ventricle was made ischemic for 20 min by ligating the left anterior descending coronary artery, and then reperfused for 120 min. Dimethylsulfoxide or minoxidil (0.3, or 1.0 mg/kg) was injected intravenously 10 min before ligation. Ischemia decreased regional myocardial contraction, and reperfusion recovered it but incompletely. Myocardial metabolic derangement was observed during ischemia, such as decreases in the myocardial levels of ATP and creatine phosphate. These metabolic changes caused by ischemia were restored by reperfusion. Minoxidil injection at 0.3 and 1.0 mg/kg significantly decreased blood pressures but increased coronary flow. Pretreatment with minoxidil significantly enhanced the recovery of myocardial contraction during reperfusion after ischemia. The levels of ATP and creatine phosphate in the ischemic myocardium were significantly preserved by minoxidil at 0.3 mg/kg. No significant effect of minoxidil on the metabolism was observed in the 120 min reperfused myocardium. In conclusion, minoxidil improved the mechanical dysfunction in the reperfused heart and the drug at low dose preserved high-energy phosphates during ischemia.

【 授权许可】

Unknown