Functional Study on Nitroxidergic Nerve in Isolated Dog Pulmonary Arteries and Veins

The Japanese Journal of Pharmacology

Kazuhide Ayajiki¹  Noboru Toda¹  Tomio Okamura¹  Kumiko Noda² 

[1] Department of Pharmacology, Shiga University of Medial Science;Research Laboratories, Nippon Shinyaku Co.

关键词: Nicotine;    Nitroxidergic (nitrergic) nerve;    Pulmonary vasculature;   

DOI  :  10.1254/jjp.89.197

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(5)In dog pulmonary arterial and venous strips without endothelium under treatment with prazosin, nicotine induced relaxation that was abolished by NG-nitro-L-arginine, hexamethonium and methylene blue. L-Arginine antagonized the NG-nitro-L-arginine action. Neurogenic relaxations tended to be more evident in the vein. Nitric oxide (NO)-induced relaxations were greater in the veins than in the arteries. Concentrations of NO to induce the same magnitude of relaxation as that to nicotine were higher in the arteries. In conclusion, dog pulmonary arteries and veins are innervated by nitroxidergic (nitrergic) nerves, and NO is released by nerve stimulation with nicotine in a larger amount in the artery than the vein.

【 授权许可】

Unknown