A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells

The Japanese Journal of Pharmacology

Yasuko Shiota¹  Masato Sugii¹  Rumi Nojiri¹  Masanori Takaoka¹  Mamoru Ohkita¹  Yasuo Matsumura¹ 

[1] Department of Pharmacology, Osaka University of Pharmaceutical Sciences

关键词: Nuclear factor-κB;    Endothelin-1;    Tumor necrosis factor-α;   

DOI  :  10.1254/jjp.89.81

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(18)BAY 11-7082, an inhibitor of nuclear factor-κB (NF-κB), which prevents a step of the phosphorylation of inhibitory protein IκB bound to NF-κB, suppressed basal and tumor necrosis factor (TNF)-α-induced prepro endothelin (ET)-1 mRNA expression and NF-κB activation in cultured vascular endothelial cells. BAY 11-7082 significantly decreased basal and TNF-α-induced ET-1 release from endothelial cells. These results indicate that the inhibition of NF-κB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression and ET-1 release, thereby suggesting that NF-κB plays an important role in the regulation of ET-1 production.

【 授权许可】

Unknown