Inhibitory Effects of Pre-ischemic and Post-ischemic Treatment With FR 168888, a Na+/H+ Exchange Inhibitor, on Reperfusion-Induced Ventricular Arrhythmias in Anesthetized Rat

The Japanese Journal of Pharmacology

Kazunori Kamiya²  Sadayoshi Komori¹  Shigeki Miyamoto²  Keitaro Hashimoto²  Bing-Mei Zhu² 

[1] Department of Human Science, Yamanashi Medical University;Department of Pharmacology, Yamanashi Medical University

关键词: Na+/H+ exchange;    Arrhythmia;    Ischemia;    Reperfusion;    FR 168888;   

DOI  :  10.1254/jjp.88.93

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(31)Cited-By(4)Effects of pre-ischemic and post-ischemic treatment with FR 168888 (5-hydroxymethyl-3-(pyrrol-l-yl) benzoylguanidine methanesulfonate), a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias were examined in an ischemia/reperfusion model of anesthetized rat. FR 168888 (0.3 mg/kg) significantly reduced the incidence of ventricular fibrillation (VF) and mortality induced by reperfusion following 5-min coronary occlusion, when it was intravenously administered 5 min before coronary artery occlusion. Post-ischemic treatment with FR 168888 (0.3 – 10 mg/kg), i.e. given 3 min after the start of occlusion, reduced the incidence of VF and mortality. In order to examine the optimal time of administration, FR 168888 (3 mg/kg) was administered 1 or 3 min after the start of occlusion or immediately before reperfusion. There was no significant difference in the reduction of VF and mortality among the three post-ischemic treatment groups. FR 168888 (3 and 10 mg/kg) significantly increased the blood pressure during ischemia without affecting the heart rate. These results indicate that FR 168888 has antiarrhythmic effects on reperfusion-induced arrhythmias even administered after coronary occlusion.

【 授权许可】

Unknown