Characteristics of Learning and Memory Impairment Induced by Δ9-Tetrahydrocannabinol in Rats

The Japanese Journal of Pharmacology

Katsunori Iwasaki¹  Michihiro Fujiwara¹  Nobuaki Egashira¹  Kenichi Mishima¹  Megumi Fujii¹  Nobue Hirosawa¹  Yoshiaki Matsumoto² 

[1] Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University;Department of Pharmacology, School Nurse Training, Kyushu Women’s Jr. College

关键词: 8-Arm radial maze;    Δ9-Tetrahydrocannabinol;    Passive avoidance;    Water maze;    Working memory;   

DOI  :  10.1254/jjp.87.297

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(34)Cited-By(39)We investigated the characteristics of Δ9-tetrahydrocannabinol (THC)-induced impairment of learning and memory using an 8-arm radial maze task, a water maze, a visual discrimination task with 2 figures and a passive avoidance test in rats. THC (6 mg/kg, i.p.) impaired spatial memory in the standard task of the 8-arm radial maze. THC (4 – 6 mg/kg, i.p.) selectively impaired working memory in a reference and working memory task of the 8-arm radial maze. Even at a dose of 10 mg/kg, THC did not impair spatial memory in the water maze. In addition, THC at a dose of 6 mg/kg, which had inhibitory effects in the 8-arm radial maze, did not affect performance in the visual discrimination task. These results indicate that at low doses (2 – 6 mg/kg), THC may not produce visual function abnormalities. THC impaired retrieval (6 mg/kg, i.p.) as well as acquisition (10 mg/kg, i.p.) in the passive avoidance test. The consolidation process was also impaired by i.c.v. injection (100 μg), but not i.p. injection (6 – 10 mg/kg) of THC. These results suggest that THC-induced impairment of spatial memory is based on the selective impairment of working memory through its effects on acquisition and retrieval processes.

【 授权许可】

Unknown