2-Arachidonoylglycerol and Anandamide Oppositely Modulate Norepinephrine Release from the Rat Heart Sympathetic Nerves

The Japanese Journal of Pharmacology

Hitoshi Kato²  Michiru Nishigaki²  Takayuki Sugiura¹  Shinji Nakane¹  Shigeto Suzuki²  Yoko Okubo²  Yoshinobu Takata²  Junichi Kurihara²  Keizo Waku¹ 

[1] Department of Hygienic Chemistry and Nutrition, Faculty of Pharmaceutical Sciences, Teikyo University;Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University

关键词: 2-Arachidonoylglycerol;    Anandamide;    Norepinephrine release;   

DOI  :  10.1254/jjp.87.93

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(5)Anandamide (10–7 and 10–6 M) as well as a synthetic cannabinoid HU210 (10–8 to 10–6 M) suppressed the norepinephrine release evoked by perivascular nerve stimulation (PNS) of the rat heart Langendorff’s preparation. The effects of HU210 and the lower dose of anandamide were completely blocked by the cannabinoid CB1-receptor antagonist AM251, while that of anandamide at 10–6 M was partly mediated by arachidonate-derived metabolites. 2-Arachidonoylglycerol (2-AG), at 10–6 M in the presence of DFP and indomethacin, increased PNS-evoked norepinephrine release, which was completely blocked by AM251. The present results suggest that the two endocannabinoids may oppositely participate in the CB1-receptor-mediated modulation of sympathetic norepinephrine release.

【 授权许可】

Unknown