Time-Dependent Apoptotic Development and Pro-apoptotic Genes Expression in Rat Heart After Myocardial Infarction

The Japanese Journal of Pharmacology

Zhong Jing Wang²  Thomas Unger¹  Yi-Chun Zhu³  Yi Zhun Zhu²  How Sung Lee²  Qing Lu² 

[1] Department of Pharmacology, University of Kiel;Department of Pharmacology, National University of Singapore;Department of Physiology, Shanghai Medical University

关键词: Myocardial infarction;    Gene expression;    Apoptosis;   

DOI  :  10.1254/jjp.86.355

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(18)We investigated the apoptotic development and apoptotic-related gene expression after myocardial infarction (MI) at different time points in the current study. Bax gene expression was increased at 12 h after MI and peaked at 24 h. Fas gene started to over-express at 12 h after MI as well but it reached maximum at 72 h. In the MI groups, strongest staining of apoptosis was detected in rats 3 days post operation. Our results demonstrate that apoptotic development after MI is time dependent in the ischemic area and there could be some linkage with the over expression of angiotensin II receptors post MI.

【 授权许可】

Unknown