Comparison of Noradrenergic and Serotonergic Antidepressants in Reducing Immobility Time in the Tail Suspension Test

The Japanese Journal of Pharmacology

Taiichiro Imanishi¹  Jun Baba¹  Jun Fujishiro²  Kenji Kosaka² 

[1] Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.;Department of Psychiatry, Yokohama City University School of Medicine

关键词: Tail suspension test;    Antidepressant;    Immobility time;   

DOI  :  10.1254/jjp.85.327

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(8)We examined the effects of two noradrenergic tricyclic antidepressants and two selective serotonin re-uptake inhibitors in the tail suspension test, with a suspension period of 30 min instead of the usual 10 min. Within the first 10 min, desipramine, nortriptyline and fluvoxamine significantly reduced the duration of immobility. Whereas desipramine and nortriptyline were also efficacious in the rest of the test period, fluvoxamine was not. Fluoxetine showed no significant effect throughout the study period. These results suggest that a prolonged tail suspension test results in functional changes in the noradrenergic and serotonergic systems and alters the sensitivity to antidepressants.

【 授权许可】

Unknown