The Role of Nitrergic System in Lidocaine-Induced Convulsion in the Mouse

The Japanese Journal of Pharmacology

Suleyman Celik¹  Yuksel Kesim¹  S. Sirri Bilge¹  Osman Kukula¹  Mehmet Kurt¹ 

[1] Department of Pharmacology, Faculty of Medicine, Ondokuz Mayis University

关键词: Lidocaine;    Convulsions;    N-nitro-L-arginine-methyl ester;    L-arginine;   

DOI  :  10.1254/jjp.85.92

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(23)Cited-By(7)The effects of N-nitro-L-arginine-methyl ester (L-NAME) a nitric oxide (NO) synthase inhibitor and L-arginine, a NO precursor, were investigated on lidocaine-induced convulsions. In the first experiment, four groups of mice received physiological saline (0.9%), L-arginine (300 mg/kg, i.p.), L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg), respectively. Thirty minutes after these injections, all mice received lidocaine (50 mg/kg, i.p.). In the second experiment, four groups of mice received similar treatment in the first experiment, and 30 min after these injections, all mice received a higher dose of lidocaine (80 mg/kg). L-NAME (100 mg/kg, i.p.) and diazepam (2 mg/kg) significantly decreased the incidence of lidocaine (50 mg/kg)-induced convulsions. In contrast, the L-arginine treatment increased the incidence of lidocaine (80 mg/kg, i.p.)-induced convulsions significantly. These results may suggest that NO is a proconvulsant mediator in lidocaine-induced convulsions.

【 授权许可】

Unknown