Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

The Japanese Journal of Pharmacology

Kazumi Kasajima¹  Nobuaki Matsui¹  Masaaki Akagi¹  Nobuyuki Fukuishi¹  Ikuko Satsuki¹  Yuka Morita¹  Reiko Kanoh¹  Keiichi Inaizumi¹ 

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima 770-8514, Japan

关键词: Xanthine oxidase;    Nuclear factor kappa B;    Reactive oxygen species;   

DOI  :  10.1254/jjp.84.363

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(15)The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.

【 授权许可】

Unknown