Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats

The Japanese Journal of Pharmacology

Shigenori Watanabe⁴  Takao Shimazoe⁴  Junichi Ishida⁴  Akihiro Funakoshi¹  Kyoko Miyasaka³  Akira Kono¹  Miyuki Maetani⁴  Tomohiro Yakabe²  Masatoshi Yamaguchi² 

[1]National Kyushu Cancer Center,Fukuoka 811-1395,Japan

[2]Department of Analytical Chemistry,Faculty of Pharmaceutical Sciences,Fukuoka University,Fukuoka 814-0180,Japan

[3]Department of Clinical Physiology,Tokyo Metropolitan Institute of Gerontology,Tokyo 173-0015,Japan

[4]Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Kyushu University,Fukuoka 812-8582,Japan

关键词: Streptozotocin;    Suprachiasmatic nucleus;    Entrainment;   

DOI  :  10.1254/jjp.83.355

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(6)The term for re−entrainment to a new light−dark cycle in streptozotocin(STZ)−induced diabetic rats was significantly longer than that in control rats.In STZ−induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application.Therefore, 5−HT function in the hypothalamus is thought to be decreased in STZ−induced diabetic rats.These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ−induced diabetic rats.Therefore, 5−HT mechanisms may play an important role in the maintenance of this function.

【 授权许可】

Unknown