Changes in Seizure Susceptibility to Local Anesthetics by Repeated Administration of Cocaine and Nomifensine but Not GBR12935:Possible Involvement of Noradrenergic System

The Japanese Journal of Pharmacology

Tomoyuki Sato¹  Toshihiro Dohi¹  Shigeo Kitayama¹  Tetsurou Ikeda¹  Katsuya Morita¹ 

[1] Department of Pharmacology,Hiroshima University School of Dentistry,Kasumi 1-2-3,Minami-ku,Hiroshima 734-8553,Japan

关键词: Local anesthetic;    Convulsion;    Monoamine transporter;   

DOI  :  10.1254/jjp.83.265

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(4)We examined cross−sensitization of cocaine and synthetic local anesthetics to their seizure susceptibility after repeated administration.Seizure susceptibility of procaine and lidocaine increased after the end of two days of treatment with a subconvulsive dose of cocaine.Acute treatment with nomifensine but not GBR12935, a specific inhibitor of the dopamine transporter, facilitated lidocaine−induced convulsion.Furthermore, daily treatment with nomifensine for two days enhanced lidocaine−induced convulsion.These results suggest the possible involvement of the brain noradrenergic system in the changes in seizure susceptibility after repeated administration of some local anesthetics.

【 授权许可】

Unknown