Decrease of Sexual Receptivity by Prolylendopeptidase Inhibitor in Female Rats

The Japanese Journal of Pharmacology

Izumi Oosuka²  Korehito Yamanouchi²  Naoyoshi Miura¹  Yoshiaki Tanaka¹ 

[1] Central Research Laboratories,Zeria Pharmaceutical Co.,Ltd.,2512-1,Oshikiri,Konan-machi,Osato-gun,Saitama 360-0111,Japan;Laboratory of Neuroendocrinology,Department of Basic Human Sciences,School of Human Sciences,Waseda University,2-579-15,Mikajima,Tokorozawa,Saitama 359-1192,Japan

关键词: Prolylendopeptidase inhibitor;    Peptide neurotransmitter;    Lordosis;   

DOI  :  10.1254/jjp.83.82

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(17)The effects of a prolylendopeptidase inhibitor, 1−[3−(2−indanylanylacetyl)−L−thioprolyl]pyrrolidine(Z−321), on lordosis behavior were investigated in estrogen and progestrone−treated ovariectomized rats.Females were orally administered 100, 200 or 300 mg/kg Z−321 or the vehicle(control).The mean lordosis quotient in the rats given 300 mg/kg Z−321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z−321 was not lower.Thus, Z−321 suppressed lordosis in estrogen and progesterone−treated ovariectomized rats.Peptide neurotransmitters, especially those containing proline, are though to be involved in the inhibitory mechanisms for lordosis behavior.

【 授权许可】

Unknown